Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.febslet.2011.05.004
Title: Are retinoids potential therapeutic agents in disorders of social cognition including autism?
Authors: Ebstein, R.P. 
Mankuta, D.
Yirmiya, N.
Malavasi, F.
Keywords: All-trans retinoic acid (ATRA)
Autism spectrum disorder (ASD)
CD38
Oxytocin
Polymorphism
Issue Date: 6-Jun-2011
Source: Ebstein, R.P.,Mankuta, D.,Yirmiya, N.,Malavasi, F. (2011-06-06). Are retinoids potential therapeutic agents in disorders of social cognition including autism?. FEBS Letters 585 (11) : 1529-1536. ScholarBank@NUS Repository. https://doi.org/10.1016/j.febslet.2011.05.004
Abstract: Increasing evidence suggests that the nonapeptide, oxytocin (OT), helps shape social and affiliative behaviors not only in lower mammals but also in humans. Recently, an essential mediator of brain OT release has been discovered, ADP-ribosyl cyclase and/or CD38. We have subsequently shown that polymorphisms across the CD38 gene are associated with autism spectrum disorders (ASD). Notably, CD38 expression in lymphoblastoid cells (LBC) is reduced in cell lines derived from ASD subjects compared to parental cell lines. Intriguingly, a correlation was observed between CD38 expression and measures of social function in ASD. Finally, we have shown that all-trans retinoic acid (ATRA), a known inducer of CD38 transcription, can rescue low CD38 expressing LBC lines derived from ASD subjects and restore normal levels of transcription of this ectoenzyme providing 'proof of principle' in a peripheral model that retinoids are potential therapeutic agents in ASD. © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Source Title: FEBS Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/49955
ISSN: 00145793
DOI: 10.1016/j.febslet.2011.05.004
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