Please use this identifier to cite or link to this item:
Title: Paracingulate sulcus asymmetry; Sex difference, correlation with semantic fluency and change over time in adolescent onset psychosis
Authors: Clark, G.M.
Mackay, C.E.
Davidson, M.E.
Iversen, S.D.
Collinson, S.L. 
James, A.C.
Roberts, N.
Crow, T.J.
Keywords: Adolescents
Sex differences
Issue Date: Oct-2010
Citation: Clark, G.M., Mackay, C.E., Davidson, M.E., Iversen, S.D., Collinson, S.L., James, A.C., Roberts, N., Crow, T.J. (2010-10). Paracingulate sulcus asymmetry; Sex difference, correlation with semantic fluency and change over time in adolescent onset psychosis. Psychiatry Research - Neuroimaging 184 (1) : 10-15. ScholarBank@NUS Repository.
Abstract: The left paracingulate sulcus (PCS) is longer than the right and the adjacent cortex is activated by the generation of words. In adult patients with chronic schizophrenia the anatomical asymmetry is reduced. In 35 controls and 38 adolescents with schizophrenia or schizoaffective disorder (mean age = 16 years) we found that semantic verbal fluency correlated with leftward PCS asymmetry in controls but not in patients. At intake, PCS length did not differ between patients and controls, but at follow-up (13 controls, 10 patients, mean age = 18 years) PCS asymmetry (comprising both increasing left and decreasing right length) increased significantly, the increase was greater in males than in females, and there was a trend for a diagnosis * sex * side * time interaction such that in controls leftward PCS asymmetry increased, while in patients of both sexes there was convergence toward symmetry. Thus sulcal anatomy develops differentially in the two sexes during adolescence, and the pattern of asymmetric sex-dependent change over time may distinguish patients with psychosis from controls. Greater change in asymmetry during adolescence may explain earlier age of onset in males and greater deficits in verbal fluency. © 2010 Elsevier Ireland Ltd.
Source Title: Psychiatry Research - Neuroimaging
ISSN: 09254927
DOI: 10.1016/j.pscychresns.2010.06.012
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Feb 21, 2019


checked on Feb 4, 2019

Page view(s)

checked on Mar 11, 2018

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.