Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.yhbeh.2011.04.005
Title: Vasopressin needs an audience: Neuropeptide elicited stress responses are contingent upon perceived social evaluative threats
Authors: Shalev, I.
Israel, S.
Uzefovsky, F.
Gritsenko, I.
Kaitz, M.
Ebstein, R.P. 
Keywords: Arginine vasopressin
Intranasal
Salivary cortisol
Social cognition
Stress
Trier Social Stress Test
Issue Date: Jun-2011
Source: Shalev, I.,Israel, S.,Uzefovsky, F.,Gritsenko, I.,Kaitz, M.,Ebstein, R.P. (2011-06). Vasopressin needs an audience: Neuropeptide elicited stress responses are contingent upon perceived social evaluative threats. Hormones and Behavior 60 (1) : 121-127. ScholarBank@NUS Repository. https://doi.org/10.1016/j.yhbeh.2011.04.005
Abstract: The nonapeptide arginine vasopressin (AVP) plays an important role in hypothalamus-pituitary-adrenal axis regulation and also functions as a social hormone in a wide variety of species, from voles to humans. In the current report we use a variety of stress inducing tasks, including the Trier Social Stress Test (TSST) and intranasal administration of AVP to show that intranasal administration of this neuropeptide leads to a significant increase in salivary cortisol and pulse rate, specifically in conditions where subjects perform tasks in the presence of a social evaluative threat (task performance could be negatively judged by others). In contrast, in conditions without a social evaluative threat (no task condition, modified TSST without audience and bike ergometry), subjects receiving AVP did not differ from subjects receiving placebo. Thus exogenous AVP's influence is contingent upon a circumscribed set of initial conditions that constitute a direct threat to the maintenance of our social selves. Stress evoked by social threat is an integral part of social life and is related to self-esteem and in extreme forms, to poor mental health (e.g., social phobia). Our findings suggest that AVP is a key component in the circuit that interlaces stress and social threat and findings offer inroads to our understanding of individual differences in sociability and in stress response elicited in threatening social situations. © 2011 Elsevier Inc.
Source Title: Hormones and Behavior
URI: http://scholarbank.nus.edu.sg/handle/10635/49915
ISSN: 0018506X
DOI: 10.1016/j.yhbeh.2011.04.005
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

32
checked on Dec 13, 2017

WEB OF SCIENCETM
Citations

31
checked on Oct 28, 2017

Page view(s)

51
checked on Dec 9, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.