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Title: The role of TFF3 in cytotoxic drug resistance of breast cancer
Keywords: TFF3, breast cancer, drug resistance, docetaxel, doxorubicin, BCL-2
Issue Date: 13-Mar-2013
Citation: ZHANG WANQIU (2013-03-13). The role of TFF3 in cytotoxic drug resistance of breast cancer. ScholarBank@NUS Repository.
Abstract: Cytotoxic drugs like docetaxel and doxorubicin play a vital role in breast cancer therapy. However drug resistance limits their usefulness. In addition to accumulating evidence indicating a role of TFF3 in oncogenicity of several carcinomas, TFF3 has been revealed to be involved in drug resistance. This study demonstrated that TFF3 mediated cytotoxic drug resistance in mammary carcinoma cells. TFF3 promoted colony formation in soft agar and cell growth in 3D Matrigel of MCF-7 cells in a BCL-2 dependent manner. Forced expression of TFF3 reduced docetaxel and doxorubicin sensitivity in MCF-7 cells. Conversely, depletion of TFF3 with siRNA increased docetaxel sensitivity. Furthermore, expression of TFF3 was upregulated in mammary carcinoma cells with acquired docetaxel resistance and its expression was further induced by docetaxel treatment. Given the role of TFF3 in oncogenicity of mammary carcinoma and drug resistance to chemotherapeutic agents, TFF3 may represent a potential target in treatment of breast cancer.
Appears in Collections:Master's Theses (Open)

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