Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/49589
Title: CHARACTERIZING ROLES OF ANNEXIN-1 IN BREAST CANCER DEVELOPMENT BY MASS SPECTROMETRY - BASED QUANTITATIVE PROTEOMICS
Authors: SWA LEE FOON HANNAH
Keywords: Annexin-1, Breast Cancer Development, Quantitative Proteomics, Mass Spectrometry, SILAC, Super-SILAC
Issue Date: 19-Aug-2013
Source: SWA LEE FOON HANNAH (2013-08-19). CHARACTERIZING ROLES OF ANNEXIN-1 IN BREAST CANCER DEVELOPMENT BY MASS SPECTROMETRY - BASED QUANTITATIVE PROTEOMICS. ScholarBank@NUS Repository.
Abstract: Annexin-1 (ANXA1) has been reported to be involved in important physio-pathological implications including cell proliferation, apoptosis, cancer and metastasis. However, with controversies in ANXA1 expression in breast carcinomas, its role in breast cancer initiation and progression remains unclear. The study presented here seeks to characterize ANXA1 in initiation and tumorigenesis of breast cancer by understanding the dysregulated pathways involved. Through quantitative mass spectrometry-based proteomics, SILAC (stable isotope labelling by amino acids in cell culture) and Super-SILAC were applied to normal mammary gland cells and mammary tumors respectively from ANXA1-heterozygous (ANXA1+/-) and null (ANXA1-/-) mice to study their changes at the proteome level.
URI: http://scholarbank.nus.edu.sg/handle/10635/49589
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