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https://scholarbank.nus.edu.sg/handle/10635/49561
DC Field | Value | |
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dc.title | ORAL PROBIOTIC EFFECT OF LACTOBACILLUS CASEI SHIROTA ON STREPTOCOCCUS MUTANS | |
dc.contributor.author | CHEN HUIZHEN | |
dc.date.accessioned | 2014-03-28T18:00:15Z | |
dc.date.available | 2014-03-28T18:00:15Z | |
dc.date.issued | 2013-08-23 | |
dc.identifier.citation | CHEN HUIZHEN (2013-08-23). ORAL PROBIOTIC EFFECT OF LACTOBACILLUS CASEI SHIROTA ON STREPTOCOCCUS MUTANS. ScholarBank@NUS Repository. | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/49561 | |
dc.description.abstract | Probiotic treatments have demonstrated promising effects in dental caries prevention. However, the exact mechanisms remain unclear. Yakult? is a probiotic drink containing live Lactobacillus casei Shirota. There is no study reporting the effect of Yakult? or L. casei Shirota on the cariogenic bacterium Streptococcus mutans to date. In this study, Yakult? and L. casei Shirota decreased S. mutans biofilm formation on tooth surface with reduced biofilm acidogenicity and lesion depth in enamel. L. casei Shirota decreased S. mutans extracellular polysaccharide production, biofilm formation and acidogenicity by suppressing gtfB, gtfC and ldh expression. Its cell free culture supernatant inhibited the growth of S. mutans. The inhibitory compounds were heat stable and active in an acidic environment. This study has deepened the understanding of cariostatic/probiotic effect of Yakult? and L. casei Shirota, and may facilitate the clinical application of this non-fluoride ?sweet? therapy to prevent caries formation. | |
dc.language.iso | en | |
dc.subject | dental caries; biofilm; plaque pH; demineralization; probiotics; extracellular polysaccharide | |
dc.type | Thesis | |
dc.contributor.department | DENTISTRY | |
dc.contributor.supervisor | HSU CHIN-YING, STEPHEN | |
dc.description.degree | Ph.D | |
dc.description.degreeconferred | DOCTOR OF PHILOSOPHY | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Ph.D Theses (Open) |
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ChenHZ.pdf | 6.73 MB | Adobe PDF | OPEN | None | View/Download |
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