Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/49561
Title: ORAL PROBIOTIC EFFECT OF LACTOBACILLUS CASEI SHIROTA ON STREPTOCOCCUS MUTANS
Authors: CHEN HUIZHEN
Keywords: dental caries; biofilm; plaque pH; demineralization; probiotics; extracellular polysaccharide
Issue Date: 23-Aug-2013
Source: CHEN HUIZHEN (2013-08-23). ORAL PROBIOTIC EFFECT OF LACTOBACILLUS CASEI SHIROTA ON STREPTOCOCCUS MUTANS. ScholarBank@NUS Repository.
Abstract: Probiotic treatments have demonstrated promising effects in dental caries prevention. However, the exact mechanisms remain unclear. Yakult? is a probiotic drink containing live Lactobacillus casei Shirota. There is no study reporting the effect of Yakult? or L. casei Shirota on the cariogenic bacterium Streptococcus mutans to date. In this study, Yakult? and L. casei Shirota decreased S. mutans biofilm formation on tooth surface with reduced biofilm acidogenicity and lesion depth in enamel. L. casei Shirota decreased S. mutans extracellular polysaccharide production, biofilm formation and acidogenicity by suppressing gtfB, gtfC and ldh expression. Its cell free culture supernatant inhibited the growth of S. mutans. The inhibitory compounds were heat stable and active in an acidic environment. This study has deepened the understanding of cariostatic/probiotic effect of Yakult? and L. casei Shirota, and may facilitate the clinical application of this non-fluoride ?sweet? therapy to prevent caries formation.
URI: http://scholarbank.nus.edu.sg/handle/10635/49561
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
ChenHZ.pdf6.73 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

164
checked on Feb 23, 2018

Download(s)

201
checked on Feb 23, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.