Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/49373
Title: ELECTROSPUN BIOMIMETIC AND PHOTOSENSITIVE NANOFIBROUS SCAFFOLD FOR SKIN TISSUE ENGINEERING
Authors: JIN GUORUI
Keywords: Skin tissue engineering, stem cell, biomimetic scaffold, electrospun nanofibers, drug release, photosensitive scaffold
Issue Date: 19-Aug-2013
Source: JIN GUORUI (2013-08-19). ELECTROSPUN BIOMIMETIC AND PHOTOSENSITIVE NANOFIBROUS SCAFFOLD FOR SKIN TISSUE ENGINEERING. ScholarBank@NUS Repository.
Abstract: Tissue engineering has emerged as a new and promising field for the treatment of skin lesions, combining scaffolds, cells and biomolecular signals, such as growth factors. However, a critical issue of tissue engineered scaffold is the ex vivo cell expansion which is required to obtain sufficient numbers of the needed cells, while preserving the cells' normal phenotype and functionality within a short time. Interestingly, light and electrical stimulations were found to promote cell proliferation. In this project, epidermal growth factor (EGF) and photosensitive polymer poly(3-hexylthiophene) (P3HT) were encapsulated into core-shell NFS. Fibroblast proliferation was significantly improved on EGF encapsulated nanofibers and photosensitive P3HT in the core-shell nanofibers can further promoted fibroblast proliferation under light stimulation. Our study sheds light on a novel way for wound healing - photocurrent therapy.
URI: http://scholarbank.nus.edu.sg/handle/10635/49373
Appears in Collections:Ph.D Theses (Open)

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