Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/49365
Title: A mouse model of rhinovirus-induced asthma exacerbation
Authors: ZHANG XUEYU
Keywords: mouse model, rhinovirus, asthma exacerbation, inflammation, cytokines, chemokines
Issue Date: 7-Aug-2013
Source: ZHANG XUEYU (2013-08-07). A mouse model of rhinovirus-induced asthma exacerbation. ScholarBank@NUS Repository.
Abstract: Asthma is a chronic airway disease that affects millions of people around the world. The exacerbation of asthma symptoms is tightly associated with the mortality of this disease and brings a heavy healthcare and economic burden. With the development of PCR techniques, rhinovirus, the major cause of common cold, was detected in most wheezing cases and considered to be the major trigger of asthma exacerbation. The development of a mouse model of asthma exacerbation would greatly contribute to the further understanding of the relationship between rhinovirus infection and asthma exacerbation. Allergen challenge followed by rhinovirus infection induced inflammatory cells infiltration in airways, mucus hyper-secretion and increasing trend of airway hyper-responsiveness (AHR) in mice, which indicate that our mouse model successfully imitated the rhinovirus-induced allergic asthma exacerbation. Analysis of the expression of several inflammatory genes showed that rhinovirus infection increased the expression of Th2 cytokines and other inflammatory chemokines.
URI: http://scholarbank.nus.edu.sg/handle/10635/49365
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