Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/49360
Title: MOLECULAR AND NANOSCALE LUMINESCENT PROBES FOR DETECTION OF REACTIVE OXYGEN SPECIES
Authors: YAN YAN
Keywords: fluorescent probe, reactive oxygen species, transition metal complexes, quantum dots, nitrogen dioxide, hypochlorite
Issue Date: 23-Jul-2013
Source: YAN YAN (2013-07-23). MOLECULAR AND NANOSCALE LUMINESCENT PROBES FOR DETECTION OF REACTIVE OXYGEN SPECIES. ScholarBank@NUS Repository.
Abstract: Reactive oxygen species (ROS) are generated as byproducts or intermediates of the normal metabolism of oxygen. ROS play significant roles in cell signaling, homeostasis, and host defense. However, the excessive production of ROS may result in significant damage to cell structures and lead to a situation known as oxidative stress. To figure out multiple roles and action mechanisms of ROS, it is essential to develop sensitive and selective methods for ROS sensing in biological system. Among various approaches, fluorescent probes are preferred because they allow spatial and temporal monitoring and visually tracking ROS in cells and tissues. Here we present successfully developed molecular and nanoscale fluorescent probes targeting on ROS. These probes have been utilized in biological sensing, such as myeloperoxidase activity monitoring, live cell imaging and quantifying ROS scavenging ability of tea catechins, and also in environmental monitoring, like visual detection of trace amount of air pollutant in atmosphere.
URI: http://scholarbank.nus.edu.sg/handle/10635/49360
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