Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/49356
Title: QUANTIFICATION OF IRON TRANSFER FROM DIET TO THE BRAIN IN THE RAT MODEL USING STABLE ISOTOPE TECHNIQUES
Authors: CHEN JIEHUA
Keywords: Diet, Iron, Brain, Stable Isotope Techniques, Adult Rats
Issue Date: 30-Sep-2013
Source: CHEN JIEHUA (2013-09-30). QUANTIFICATION OF IRON TRANSFER FROM DIET TO THE BRAIN IN THE RAT MODEL USING STABLE ISOTOPE TECHNIQUES. ScholarBank@NUS Repository.
Abstract: Iron deposits in brain are a common hallmark of Alzheimer¿s disease (AD) and Parkinson's disease (PD), spurring the hypothesis that iron may play a functional role in the pathogenesis of AD/PD through free radical damage. Recent epidemiological studies point to a possible relationship between dietary iron intake and AD/PD. In this project, we have developed a novel methodological approach for tracing iron transfer directly from diet to brain in the adult rat using stable iron isotopes in long-term feeding experiments. Our findings challenge current beliefs in neuroscience. While only minute amounts of iron were taken up by the healthy adult brain, we found relative changes in brain iron content over time to be significant. Brain iron influx exceeded efflux significantly. Body iron homeostasis was found to override brain iron homeostasis: brain iron uptake could be lowered successfully both by increasing and decreasing iron intake relative to a control diet.
URI: http://scholarbank.nus.edu.sg/handle/10635/49356
Appears in Collections:Ph.D Theses (Open)

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