Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/49352
Title: THE ROLES OF LAMININ AND INTEGRIN a7?1 IN AIRWAY SMOOTH MUSCLE CELL FUNCTION
Authors: TEOH CHUN MING
Keywords: laminin, integrin, airway smooth muscle, survival, proliferation, calcium
Issue Date: 20-Aug-2013
Source: TEOH CHUN MING (2013-08-20). THE ROLES OF LAMININ AND INTEGRIN a7?1 IN AIRWAY SMOOTH MUSCLE CELL FUNCTION. ScholarBank@NUS Repository.
Abstract: Two cardinal features of asthma are airway wall remodeling (AWR) and airway hyperresponsiveness (AHR). AWR is defined by a number of structural changes including increased mass of contractile expressing airway smooth muscle (ASM) cells. Increased ASM mass is a principal factor underlying excessive and fixed AHR in asthma. The functional consequences of ASM cells hinge on the ability of ASM cells to undergo phenotypic switching between a contractile and a proliferative/synthetic phenotype. Accumulation of extracellular matrix (ECM) proteins such as laminin is a prominent feature of AWR. We show that laminin drives survival signals to promote a contractile smooth muscle phenotype and airway hyperreactivity. Importantly, inhibition of laminin or integrin a7?1 does not revert ASM cells from a contractile phenotype back to a proliferative/synthetic phenotype. In addition, we show that changes in calcium homeostasis are dependent on the binding of laminin to its receptor, integrin a7?1. Taken together, our studies suggest that targeting laminin and integrin a7?1 may provide new avenues for the development of therapies to reduce the increase in mass of contractile phenotype ASM cells that underlie AWR and AHR in asthma.
URI: http://scholarbank.nus.edu.sg/handle/10635/49352
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
TeohCM.pdf5.37 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

107
checked on Dec 18, 2017

Download(s)

34
checked on Dec 18, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.