Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/49350
Title: THE ROLE OF ANNEXIN-1 IN THE REGULATION OF INFLAMMATORY STRESS RESPONSE IN MACROPHAGES
Authors: SUNITHA NAIR
Keywords: Annexin-1, inflammation, stress, macrophages
Issue Date: 20-Sep-2013
Source: SUNITHA NAIR (2013-09-20). THE ROLE OF ANNEXIN-1 IN THE REGULATION OF INFLAMMATORY STRESS RESPONSE IN MACROPHAGES. ScholarBank@NUS Repository.
Abstract: Annexin-1 (ANXA1) is an anti-inflammatory protein that has a myriad of functions including its ability to function as a stress protein. ANXA1 has been shown to function as a stress protein in A549 lung cancer cells, HeLa cells and MCF-7 breast adenocarcinoma cells lines, however it is unclear how it is involved in the inflammatory stress response. Using heat as a form of stress, we studied the anti-inflammatory and protecting role of ANXA1 in bone marrow derived macrophages employing the ANXA1 KO model. LPS induced TNFa cytokine level was downregulated only in heat stressed WT cells and not in ANXA1 KO cells, indicating that ANXA1 was important in the regulation of TNFa levels during stress. Further studies revealed possible involvement of the major heat shock protein HSP70 and its relationship with JNK. MAPK and NFkB were also demonstrated to play a role in the inflammatory stress response mediated by ANXA1.
URI: http://scholarbank.nus.edu.sg/handle/10635/49350
Appears in Collections:Master's Theses (Open)

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