Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/49305
Title: MECHANISTIC INVESTIGATION OF THE ANTITUMOR, ANTI-INFLAMMATORY AND CYTOPROTECTIVE POTENTIAL OF ISOTHIOCYANATE ANALOGS
Authors: SHRIDHIVYA REDDY AMARR
Keywords: ISOTHIOCYANATES, SULFORAPHANE, anti-NFkapppaB drugs, MITOTIC INHIBITORS, Nrf2 inducers, drug discovery
Issue Date: 22-Aug-2013
Source: SHRIDHIVYA REDDY AMARR (2013-08-22). MECHANISTIC INVESTIGATION OF THE ANTITUMOR, ANTI-INFLAMMATORY AND CYTOPROTECTIVE POTENTIAL OF ISOTHIOCYANATE ANALOGS. ScholarBank@NUS Repository.
Abstract: Isothiocyanates (ITCs) derived from cruciferous vegetables possess diverse biological properties that are attributed to the reactivity of the N=C=S functional group. Analogs of naturally-occurring ITCs, namely sulforaphane, benzyl isothiocyanate and phenethyl isothiocyanate , had been synthesized previously in the laboratory and were evaluated in this PhD study for their anti-tumor and chemopreventive potential. The aromatic ITC analogs were found to display stronger anti-proliferative activities. Further biological characterization revealed that they caused cell death through inducing M phase arrest, tubulin aggregation and inhibition of thioredoxin reductase activity. On the other hand, aliphatic ITC analogs produced less cytotoxicity; at non-lethal concentrations, they were found to exhibit anti-inflammatory and cytoprotective activities that were mediated through inhibition of the TLR-4 signaling pathway and modulation the Nrf2-Keap1 pathway respectively. In conclusion, the ITC analogs possessed immense potential to be developed into clinical candidates for treatment of cancer and prevention of inflammation and carcinogenesis.
URI: http://scholarbank.nus.edu.sg/handle/10635/49305
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
AMARRShridhivyaReddy.pdf5.3 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

100
checked on Feb 23, 2018

Download(s)

35
checked on Feb 23, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.