Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/49243
Title: FUNCTIONS OF GAMMA-GLUTAMYL TRANSPEPTIDASE IN HELICOBACTER PYLORI
Authors: WONG JIN HUEI
Keywords: Helicobacter pylori, Gamma-glutamyl transpeptidase, vacuolation, epidermal growth factor receptor, interleukin-8, cellular migration
Issue Date: 16-Aug-2013
Source: WONG JIN HUEI (2013-08-16). FUNCTIONS OF GAMMA-GLUTAMYL TRANSPEPTIDASE IN HELICOBACTER PYLORI. ScholarBank@NUS Repository.
Abstract: Helicobacter pylori gamma-glutamyl transpeptidase (GGT) is a vital metabolic enzyme in glutathione metabolism and is also an important virulence factor that causes cell apoptosis and induction of immune response. This study shows that GGT enhances Vacuolating cytotoxin A (VacA)-induced vacuole formation depending on the level of vacA mRNA expression. Furthermore, GGT induced the up-regulation of epidermal growth factor receptor (EGFR) and its ligand heparin-binding epidermal growth factor (HB-EGF) leading to cell migration. It is established that the over-expression of EGFR and HB-EGF is associated with gastric cancer and that vacuolation contributes to gastric mucosal damage leading to localised chronic inflammation. Taken together, this study shows that GGT has a pivotal role in H. pylori pathogenesis.
URI: http://scholarbank.nus.edu.sg/handle/10635/49243
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Video 1_Control uninfected AGS cells.avi4.47 MBAVI

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Video 2_WT-infected AGS cells_arrows.avi8.78 MBAVI

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Video 3_mutant ggt-infected AGS cells.avi6.41 MBAVI

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01 Table of content and introduction.pdf232.75 kBAdobe PDF

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02 Literature survey and material and methods.pdf4.02 MBAdobe PDF

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03 Results_1.pdf9.07 MBAdobe PDF

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04 Results_2.pdf5.66 MBAdobe PDF

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05 Results_3.pdf9.8 MBAdobe PDF

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06 Discussion references and appendices.pdf1.27 MBAdobe PDF

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07 Publication.pdf9.75 MBAdobe PDF

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