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https://scholarbank.nus.edu.sg/handle/10635/49243
Title: | FUNCTIONS OF GAMMA-GLUTAMYL TRANSPEPTIDASE IN HELICOBACTER PYLORI | Authors: | WONG JIN HUEI | Keywords: | Helicobacter pylori, Gamma-glutamyl transpeptidase, vacuolation, epidermal growth factor receptor, interleukin-8, cellular migration | Issue Date: | 16-Aug-2013 | Citation: | WONG JIN HUEI (2013-08-16). FUNCTIONS OF GAMMA-GLUTAMYL TRANSPEPTIDASE IN HELICOBACTER PYLORI. ScholarBank@NUS Repository. | Abstract: | Helicobacter pylori gamma-glutamyl transpeptidase (GGT) is a vital metabolic enzyme in glutathione metabolism and is also an important virulence factor that causes cell apoptosis and induction of immune response. This study shows that GGT enhances Vacuolating cytotoxin A (VacA)-induced vacuole formation depending on the level of vacA mRNA expression. Furthermore, GGT induced the up-regulation of epidermal growth factor receptor (EGFR) and its ligand heparin-binding epidermal growth factor (HB-EGF) leading to cell migration. It is established that the over-expression of EGFR and HB-EGF is associated with gastric cancer and that vacuolation contributes to gastric mucosal damage leading to localised chronic inflammation. Taken together, this study shows that GGT has a pivotal role in H. pylori pathogenesis. | URI: | http://scholarbank.nus.edu.sg/handle/10635/49243 |
Appears in Collections: | Master's Theses (Open) |
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Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
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Video 1_Control uninfected AGS cells.avi | 4.47 MB | AVI | OPEN | None | Preview online | |
Video 2_WT-infected AGS cells_arrows.avi | 8.78 MB | AVI | OPEN | None | Preview online | |
Video 3_mutant ggt-infected AGS cells.avi | 6.41 MB | AVI | OPEN | None | Preview online | |
01 Table of content and introduction.pdf | 232.75 kB | Adobe PDF | OPEN | None | View/Download | |
02 Literature survey and material and methods.pdf | 4.02 MB | Adobe PDF | OPEN | None | View/Download | |
03 Results_1.pdf | 9.07 MB | Adobe PDF | OPEN | None | View/Download | |
04 Results_2.pdf | 5.66 MB | Adobe PDF | OPEN | None | View/Download | |
05 Results_3.pdf | 9.8 MB | Adobe PDF | OPEN | None | View/Download | |
06 Discussion references and appendices.pdf | 1.27 MB | Adobe PDF | OPEN | None | View/Download | |
07 Publication.pdf | 9.75 MB | Adobe PDF | OPEN | None | View/Download |
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