Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/49158
Title: Brain 3-Mercaptopyruvate Sulfurtransferase (3MST): Cellular Localization and Downregulation after Acute Stroke
Authors: ZHAO HENG
Keywords: 3-Mercaptopyruvate Sulfurtransferase, Stroke, Hydrogen Sulfide, Astrocyte, Immunohistochemistry, pMCAO
Issue Date: 7-Aug-2013
Citation: ZHAO HENG (2013-08-07). Brain 3-Mercaptopyruvate Sulfurtransferase (3MST): Cellular Localization and Downregulation after Acute Stroke. ScholarBank@NUS Repository.
Abstract: 3-Mercaptopyruvate sulfurtransferase (3MST) is an important enzyme for the synthesis of hydrogen sulfide (H2S) in the brain. We present here data that indicate an exclusively localization of 3MST in astrocytes. Regional distribution of 3MST activities is even and unremarkable. Following permanent middle cerebral artery occlusion (pMCAO), 3MST was down-regulated in both the cortex and striatum, but not in the corpus collosum. It appears that the down-regulation of astrocytic 3MST persisted in the presence of astrocytic proliferation due to gliosis. Our observations indicate that 3MST is probably not responsible for the increased production of H2S following pMCAO. Therefore, cystathionine ?-synthase (CBS), the alternative H2S producing enzyme in the CNS, remains as a more likely potential therapeutic target than 3MST in the treatment of acute stroke through inhibition of H2S production.
URI: http://scholarbank.nus.edu.sg/handle/10635/49158
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Zhao Heng.pdf7.39 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

108
checked on Aug 17, 2018

Download(s)

284
checked on Aug 17, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.