Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/49151
Title: Oxidative stress regulates DTNBPI/Dysbindin-1 Expression and Degradation via a Pest Sequence in it s C-Terminus
Authors: YAP MEI YI ALICIA
Keywords: Dysbindin-1, oxidative stress, proteasome, schizophrenia
Issue Date: 20-Aug-2013
Citation: YAP MEI YI ALICIA (2013-08-20). Oxidative stress regulates DTNBPI/Dysbindin-1 Expression and Degradation via a Pest Sequence in it s C-Terminus. ScholarBank@NUS Repository.
Abstract: Variation in the gene encoding dysbindin-1, dystrobrevin binding protein 1 (DTNBP1), has been associated with schizophrenia. Dysbindin-1 protein levels are reduced in several brain areas including the hippocampus in affected individuals. However, this may not be related to decrease DTNBP1 mRNA expression. Increasing number of studies has shown that oxidative stress resulting from the production of reactive oxygen species and nitrogen reactive species is an etiological factor in schizophrenia. Therefore, we tested whether oxidative stress modulates DTNBP1 mRNA expression. Together, findings suggest that, while oxidative stress increases DTNBP1 transcription, it strongly promotes dysbindin-1 protein degradation, leading to the reported loss of dysbindin-1 protein in the brain of schizophrenia patients.
URI: http://scholarbank.nus.edu.sg/handle/10635/49151
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