Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/49124
Title: RELAXIN-3 AND BEHAVIOUR: THE ROLE OF THE NUCLEUS INCERTUS IN FEEDING AND ANXIETY
Authors: LEE LIYING CORINNE
Keywords: Nucleus Incertus, Relaxin-3, CRF-saporin, Lesion, Rat, Anxiety
Issue Date: 23-Aug-2013
Citation: LEE LIYING CORINNE (2013-08-23). RELAXIN-3 AND BEHAVIOUR: THE ROLE OF THE NUCLEUS INCERTUS IN FEEDING AND ANXIETY. ScholarBank@NUS Repository.
Abstract: The nucleus incertus (NI), a distinct group of cells in the pontine periventricular gray of the rats¿ brains, is the chief source of relaxin-3. The robust expression of corticotropin releasing hormone receptor 1 (CRF1) and the extensive projections of the NI neurons implicated the NI in anxiety behaviour. To investigate the role of the NI in appetite and anxiety regulation, this thesis aims to establish a method using the CRF-saporin conjugate to selectively ablate the CRF1-expressing NI neurons in rats. The effect of this loss of neurons on feeding and anxiety behaviour in rats will be examined. This project also aims to question if relaxin-3 is orchestrating the actions of the NI in anxiety-like behaviour. The findings showed a marked reduction of CRF1 and relaxin-3 expressing cells. Anxiogenic-like behaviour of NI-lesioned rats in fear conditioning, open field, elevated plus maze, novelty suppressed feeding and the light-dark box was reversed by human relaxin-3 (H3) infusion into the medial/central amygdala.
URI: http://scholarbank.nus.edu.sg/handle/10635/49124
Appears in Collections:Ph.D Theses (Open)

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