Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/48865
Title: SURFACE MODIFICATION OF METALLIC ORTHOPAEDIC IMPLANTS TO ENHANCE ANTI-FIBROTIC AND ANTI-INFLAMMATORY EFFECTS USING BMP-7 DERIVATIVES
Authors: LEWIS TAN HARK CHUAN
Keywords: fibrosis, cobalt-chromium, inflammation, BMP-7, polydopamine, osteogenesis
Issue Date: 1-Aug-2013
Source: LEWIS TAN HARK CHUAN (2013-08-01). SURFACE MODIFICATION OF METALLIC ORTHOPAEDIC IMPLANTS TO ENHANCE ANTI-FIBROTIC AND ANTI-INFLAMMATORY EFFECTS USING BMP-7 DERIVATIVES. ScholarBank@NUS Repository.
Abstract: Orthopaedic metallic implants are essential in providing structural support for diseased or destroyed joints or bones. Despite the biocompatibility of metallic implants used, the repair process may lead to poor outcome like fibrosis, inflammation and ultimately implant failure. CoCr (Cobalt chromium) is one of the most commonly used orthopaedic metallic implant known for its resistance to wear and corrosion. BMP-7 growth factor has been approved by the FDA for clinical use for orthopaedic applications. The equivalent BMP-7 peptide, derived from the knuckle epitope with a conjugated cysteine amino acid at the N-terminus was chosen to study the effects on osteogenesis, inflammation and fibrosis. BMP-7 peptide can be covalently grafted onto the metallic surface using polydopamine binding for bioactive application. In vitro BMP-7 peptide grafted onto CoCr surface effects on cells showed good promise of increased osseointegration, reducing fibrosis and chronic inflammation which can help to optimize metallic implant surgical success.
URI: http://scholarbank.nus.edu.sg/handle/10635/48865
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