Effective treatment of solid tumors via Cryosurgery

Abstract

Cryosurgery has been widely accepted as a minimally invasive therapy for tumor treatment by employing freezing at extreme low temperatures. However, it frequently falls short of maximizing cryoinjury within targeted region while minimizing damage to surrounding healthy tissues. This dissertation experimentally evaluates thermal development of cryosurgical processes and the thermal impact due to the existence of large blood flow. The effects of experimental parameters on the performance of cryosurgical system have been analyzed. The mathematical models are developed to analyze the bioheat transfer with different operating procedures. These models are used to improve the efficacy of freezing process by analyzing the shape factor of complete ablation zone and thermal effect of vascular network. Besides studying the cryo-freezing process, cryosurgery can employ complementary heating tools to enhance the cryosurgical efficacy. We promote the performance of cryosurgery by incorporating the Joule heating and radiofrequency-generated heating. Incorporating heating into cryosurgery protects healthy tissue.