Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/48669
Title: Docetaxel Pharmacogenetics and its Influence on the Pharmacokinetics/Pharmacodynamics of Docetaxel in Asian Nasopharyngeal Cancer Patients
Authors: CHEW SIN CHI
Keywords: Pharmacokinetics, Asians, Nasopharyngeal cancer, Docetaxel, Regulatory nuclear receptors, Drug transporters, Drug metabolism enzymes
Issue Date: 27-Mar-2013
Source: CHEW SIN CHI (2013-03-27). Docetaxel Pharmacogenetics and its Influence on the Pharmacokinetics/Pharmacodynamics of Docetaxel in Asian Nasopharyngeal Cancer Patients. ScholarBank@NUS Repository.
Abstract: This is an exploratory study aimed at elucidating the genetic basis of inherited differences in docetaxel pharmacokinetics and pharmacodynamic in local Chinese nasopharyngeal cancer patients (N = 50). The following genes involved in the biochemical pathways of docetaxel were studied: regulatory nuclear receptors (PXR, CAR, RXRa, HNF4a), drug metabolism enzymes (CYP3A4, CYP3A5) and drug transporters (ABCB1, ABCC2, ABCG2, SLCO1B3). The docetaxel pharmacokinetic profile of the patients was characterised by high degree of interindividual variability, with approximately 4- to 6-fold variations observed in Cmax, AUC0-8 and CL. Wide interpatient difference in percentage decrease of nadir haemoglobin, absolute neutrophil count and platelet from baseline in cycle 1 was also observed. Our data showed that several SNPs and haplotypes in the genes along the biochemical pathway of docetaxel might contribute to the interindividual variability in the pharmacokinetics and pharmacodynamics of docetaxel. Our results have to be validated in a larger cohort of patients with different backgrounds.
URI: http://scholarbank.nus.edu.sg/handle/10635/48669
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