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Title: The Role of Interferon Gamma in Regulating Antigen Specific CD8 T Cell Responses in a Mouse Model of Influenza
Keywords: Interferon gamma, CD8 T cell, mouse, Influenza, Immune-regulation
Issue Date: 12-Aug-2013
Citation: NAYANA PRABHU PADUBIDHRI (2013-08-12). The Role of Interferon Gamma in Regulating Antigen Specific CD8 T Cell Responses in a Mouse Model of Influenza. ScholarBank@NUS Repository.
Abstract: The factors that regulate contraction of the CD8-T-cell response and magnitude of the memory population against influenza are currently undefined. In this study, we use a mouse model of influenza to demonstrate that absence of IFN-gamma signaling leads to aberrant contraction of antigen-specific CD8-T-cell responses. Reduced contraction was associated with an increased fraction of CD8-T-cells expressing IL-7R at the peak of the response, resulting in enhanced numbers of memory-precursor cells in IFN-gamma-/- and IFN-gammaR-/- compared to WT mice. Blocking IL-7 within the lung of IFN-gamma-/- mice restored the contraction of flu-specific CD8-T-cells, indicating that IL-7R is important for survival. Finally, enhanced CD8-T-cell recall responses and accelerated viral clearance were observed in the IFN-gamma-/- and IFN-gammaR-/- mice after a heterologous re-challenge. In summary, we have identified IFN-gamma as an important regulator of localized viral immunity that promotes the contraction of influenza-specific CD8-T-cells, thereby limiting the size of the memory cell population.
Appears in Collections:Ph.D Theses (Open)

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