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Title: Characterization of Lung Dendritic Cells in a novel Murine Model of Asthma
Authors: ZHOU QIAN
Keywords: Asthma, Blomia tropicalis, Lung CD11b+ DCs, IRF4, Epithelial cells, GM-CSF
Issue Date: 6-Aug-2013
Citation: ZHOU QIAN (2013-08-06). Characterization of Lung Dendritic Cells in a novel Murine Model of Asthma. ScholarBank@NUS Repository.
Abstract: The Blomia tropicalis (Blo t) dust mite is prevalent in tropical and sub-tropical regions of the world. Although it is a leading cause of asthma, little is known how it induces allergy. Using a novel murine asthma model induced by intra nasal exposure to Blo t, we observed that a single intranasal sensitization to Blo t extract induces strong Th2 priming in the lung draining lymph node. Resident CD11b+ DCs preferentially transport antigen from the lung to the draining lymph node and are crucial for the initiation of Th2 CD4+ T cell responses. As a consequence, mice selectively deficient in CD11b+ DCs exhibited attenuated Th2 responses and more importantly did not develop any allergic inflammation. We also show that CD11b+ DCs constitutively express higher levels of GM-CSF receptor compared to CD103+ DCs and are thus selectively licensed by lung epithelial-derived GM-CSF to induce Th2 immunity.
Appears in Collections:Ph.D Theses (Open)

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