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https://scholarbank.nus.edu.sg/handle/10635/48585
DC Field | Value | |
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dc.title | REGULATION OF RHOGAP DLC1 BY FAK, PP2A AND MEK/ERK IN CELL DYNAMICS | |
dc.contributor.author | ARCHNA RAVI | |
dc.date.accessioned | 2013-12-16T18:01:23Z | |
dc.date.available | 2013-12-16T18:01:23Z | |
dc.date.issued | 2013-08-20 | |
dc.identifier.citation | ARCHNA RAVI (2013-08-20). REGULATION OF RHOGAP DLC1 BY FAK, PP2A AND MEK/ERK IN CELL DYNAMICS. ScholarBank@NUS Repository. | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/48585 | |
dc.description.abstract | DLC1, a functional RhoGAP and tumor suppressor, affects the process of cell migration via its regulation of RhoA. A serine-rich multi-domain protein, DLC1 undergoes post-translational modifications such as phosphorylation. It has been identified as a downstream target for various kinases but effects of growth factors, which play a crucial role in the development and progression of cancer, on DLC1 have not yet been elucidated. We have identified a novel pathway involving the concerted action of Ras/Mek/Erk pathway, Focal adhesion kinase (FAK) and Protein phosphatase-2A (PP2A) to activate DLC1s GAP function. EGF stimulation not only leads to the phosphorylation of DLC1 but also that of FAK to inactivate it, thus allowing PP2A-mediated dephosphorylation at a secondary site on DLC1. This signalling cascade directly affects DLC1s effect on cell spreading and migration, which can be correlated to the reduced RhoA levels. | |
dc.language.iso | en | |
dc.subject | DLC1, regulation, cell dynamics | |
dc.type | Thesis | |
dc.contributor.department | BIOLOGICAL SCIENCES | |
dc.contributor.supervisor | LOW BOON CHUAN | |
dc.description.degree | Ph.D | |
dc.description.degreeconferred | DOCTOR OF PHILOSOPHY | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Ph.D Theses (Open) |
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RaviA.pdf | 2.95 MB | Adobe PDF | OPEN | None | View/Download |
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