Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/48403
Title: COMPREHENSIVE STUDY OF GENETIC ALTERATIONS IN GASTRIC CANCER
Authors: DENG NIANTAO
Keywords: Gastric Cancer, Copy Number Alterations, Targeted Therapy
Issue Date: 23-Aug-2013
Source: DENG NIANTAO (2013-08-23). COMPREHENSIVE STUDY OF GENETIC ALTERATIONS IN GASTRIC CANCER. ScholarBank@NUS Repository.
Abstract: Gastric cancer (GC) is a major gastrointestinal malignancy for which targeted therapies are emerging as treatment options. Using high-resolution single nucleotide polymorphism (SNP) arrays, we profiled copy number alterations in a panel of 233 gastric cancers (193 primary tumors, 40 cell lines) and 98 primary matched gastric non-malignant samples. We identified 22 recurrent focal alterations (13 amplifications and 9 deletions). These included both known targets (FGFR2, ERBB2), and also novel genes in GC (KLF5, GATA6). We found that receptor tyrosine kinase (RTK)/RAS alterations are frequent in GC and demonstrate, for the first time, that these alterations occur in a mutually exclusive fashion, with KRAS-gene amplifications highlighting a clinically relevant but previously underappreciated GC subgroup. We also show that FGFR2-amplified GCs are sensitive to dovitinib, an orally bioavailable FGFR/VEGFR targeting agent, potentially representing a subtype-specific therapy for FGFR2-amplified GCs.
URI: http://scholarbank.nus.edu.sg/handle/10635/48403
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