Please use this identifier to cite or link to this item: https://doi.org/10.1016/0920-9964(95)00023-2
Title: Further evidence for an association between schizophrenia and the HLA DQB1 gene locus
Authors: Nimgaonkar, V.L.
Zhang, X.R.
Rudert, W.A.
Trucco, M.
Tsoi, W.-F. 
Saha, N. 
Keywords: Association
Genetics
HLA
HLA DQB1
Schizophrenia
Issue Date: 1996
Citation: Nimgaonkar, V.L., Zhang, X.R., Rudert, W.A., Trucco, M., Tsoi, W.-F., Saha, N. (1996). Further evidence for an association between schizophrenia and the HLA DQB1 gene locus. Schizophrenia Research 18 (1) : 43-49. ScholarBank@NUS Repository. https://doi.org/10.1016/0920-9964(95)00023-2
Abstract: A case-control study was conducted in Singapore, in order to examine a proposed association between schizophrenia and the HLA DQB1 gene locus. The probands were male inpatients of Chinese ethnicity with schizophrenia (ICD-10 criteria, n = 102) and the controls were adults matched for gender and ethnicity (n = 111). Polymorphisms of the HLA DQB1 gene were examined using molecular typing by reverse dot-blotting (MTRB), a novel PCR based method. Among the patients, a positive association with HLA DQB1*0303 (odds ratio 4.46, C.I. 1.63, 12.17), as well as a negative association with HLA DQB1*0602 (odds ratio 0.22, C.I. 0.18, 0.83) was detected.
Source Title: Schizophrenia Research
URI: http://scholarbank.nus.edu.sg/handle/10635/48174
ISSN: 09209964
DOI: 10.1016/0920-9964(95)00023-2
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