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|Title:||Further evidence for an association between schizophrenia and the HLA DQB1 gene locus|
|Citation:||Nimgaonkar, V.L., Zhang, X.R., Rudert, W.A., Trucco, M., Tsoi, W.-F., Saha, N. (1996). Further evidence for an association between schizophrenia and the HLA DQB1 gene locus. Schizophrenia Research 18 (1) : 43-49. ScholarBank@NUS Repository. https://doi.org/10.1016/0920-9964(95)00023-2|
|Abstract:||A case-control study was conducted in Singapore, in order to examine a proposed association between schizophrenia and the HLA DQB1 gene locus. The probands were male inpatients of Chinese ethnicity with schizophrenia (ICD-10 criteria, n = 102) and the controls were adults matched for gender and ethnicity (n = 111). Polymorphisms of the HLA DQB1 gene were examined using molecular typing by reverse dot-blotting (MTRB), a novel PCR based method. Among the patients, a positive association with HLA DQB1*0303 (odds ratio 4.46, C.I. 1.63, 12.17), as well as a negative association with HLA DQB1*0602 (odds ratio 0.22, C.I. 0.18, 0.83) was detected.|
|Source Title:||Schizophrenia Research|
|Appears in Collections:||Staff Publications|
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