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|Title:||Chitosan nanoparticles containing plasmid DNA encoding house dust mite allergen, Der p 1 for oral vaccination in mice|
Der p 1
|Citation:||Chew, J.L., Wolfowicz, C.B., Chua, K.Y., Mao, H.-Q., Leong, K.W. (2003). Chitosan nanoparticles containing plasmid DNA encoding house dust mite allergen, Der p 1 for oral vaccination in mice. Vaccine 21 (21-22) : 2720-2729. ScholarBank@NUS Repository. https://doi.org/10.1016/S0264-410X(03)00228-7|
|Abstract:||Our previous studies indicated that intramuscular (i.m.) immunisation with full length Der p 1 cDNA induced significant humoral response to the left domain (approximately corresponding to amino acids 1-116) but not to the right domain (approximately corresponding to amino acids 117-222) of Der p 1 allergen. This study explored the use of chitosan-DNA nanoparticles for oral immunisation to induce immune responses specific to both the left and right domains of Der p 1. DNA constructs pDer p 1 (1-222) and pDer p 1 (114-222) were complexed with chitosan and delivered orally followed by an i.m. injection of pDer p 1 (1-222) 13 weeks later. Such approach has successfully primed Th1-skewed immune responses against both domains of Der p 1. This strategy could be further optimised for more efficacious gene vaccination for full length Der p 1. © 2003 Elsevier Science Ltd. All rights reserved.|
|Appears in Collections:||Staff Publications|
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