Please use this identifier to cite or link to this item: https://doi.org/10.1016/0041-3879(90)90075-J
Title: Changes in serum proteins (albumin, immunoglobulins and acute phase proteins) in pulmonary tuberculosis during therapy
Authors: Wong, C.T. 
Saha, N. 
Issue Date: 1990
Source: Wong, C.T., Saha, N. (1990). Changes in serum proteins (albumin, immunoglobulins and acute phase proteins) in pulmonary tuberculosis during therapy. Tubercle 71 (3) : 193-197. ScholarBank@NUS Repository. https://doi.org/10.1016/0041-3879(90)90075-J
Abstract: Serum levels of three immunoglobulins (IgG, IgA and IgM), albumin and six acute phase proteins (α1-antitrypsin, haptoglobin, transferrin, α2-macroglobulin, complements C3 and C4) were measured by immunoelectrophoresis in 57 patients with pulmonary tuberculosis when they were first diagnosed, and followed at 1 month, 2 month and 4 month intervals during anti-tuberculosis treatment. These values were compared to those from 41 healthy controls. Significant increases were observed in the initial values of serum IgG, IgM, α1-antitrypsin and haptoglobin, while transferrin and α2-macroglobulin levels were significantly reduced. No changes were observed in the levels of serum albumin, IgA and complement C3. Levels of all measured proteins decreased with treatment. However, at 4 months, IgG and α1-antitrypsin were still significantly elevated when compared to control values, while the level of haptoglobin had decreased to a level significantly lower than that of the control value.
Source Title: Tubercle
URI: http://scholarbank.nus.edu.sg/handle/10635/48155
ISSN: 00413879
DOI: 10.1016/0041-3879(90)90075-J
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