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Title: Variation of the platelet glycoprotein IIIa PIA1/A2allele frequencies in the three ethnic groups of Singapore
Authors: Lim, J.
Ng, K.C.
Ng, K.-S.
Lal, S.
Saha, N. 
Heng, C.-K. 
Keywords: Coronary artery disease
Ethnic variation
Ischaemic heart disease
Issue Date: 2003
Citation: Lim, J., Ng, K.C., Ng, K.-S., Lal, S., Saha, N., Heng, C.-K. (2003). Variation of the platelet glycoprotein IIIa PIA1/A2allele frequencies in the three ethnic groups of Singapore. International Journal of Cardiology 90 (2-3) : 269-273. ScholarBank@NUS Repository.
Abstract: Background: Polymorphisms of the glycoprotein IIIa receptor have been shown to be associated with differences in platelet aggregability. The PI A2 variant of the polymorphism has been reported to be an inherited risk factor for acute coronary events. Although the allele frequency of this polymorphism is well documented in Caucasian populations, studies involving Asian Indians, Malays and Chinese are lacking. We studied 706 random male individuals to determine the genotypic distribution of this polymorphism in Singapore. Methods: Male subjects included in this study were drawn from those undergoing routine annual medical examinations offered by their employers. Venous blood was obtained from these patients after an overnight fast and from which genomic DNA was extracted. Genotyping was carried out by polymerase chain reaction (PCR) followed by digestion with restriction enzyme NciI. Personal and family medical history of the subjects were also taken. Results: The genotype distribution of the individuals studied was in accordance to a population at Hardy Weinberg equilibrium. The frequency of the PIA2 allele was 0.1, 0.01 and 0.01 in the Indians, Malays and Chinese, respectively. The differences in frequencies of the PIA2 variant are significant among different ethnic groups (P<0.001 for Indians vs. Chinese and Indians vs. Malays). Conclusions: We observed a significantly higher frequency of the PIA2 allele among Indians relative to the Chinese and Malays in Singapore. The effect of this genotype may partially explain the higher rate of ischaemic heart disease seen among Indians compared to the Chinese and Malay ethnic groups. © 2003 Elsevier Ireland Ltd. All rights reserved.
Source Title: International Journal of Cardiology
ISSN: 01675273
DOI: 10.1016/S0167-5273(02)00567-3
Appears in Collections:Staff Publications

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