Please use this identifier to cite or link to this item:
https://doi.org/10.1016/S0264-410X(02)00485-1
DC Field | Value | |
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dc.title | Expression and immunogenicity of the major house dust mite allergen Der p 1 following DNA immunization | |
dc.contributor.author | Wolfowicz, C.B. | |
dc.contributor.author | HuangFu, T. | |
dc.contributor.author | Chua, K.Y. | |
dc.date.accessioned | 2013-11-18T08:29:07Z | |
dc.date.available | 2013-11-18T08:29:07Z | |
dc.date.issued | 2003 | |
dc.identifier.citation | Wolfowicz, C.B., HuangFu, T., Chua, K.Y. (2003). Expression and immunogenicity of the major house dust mite allergen Der p 1 following DNA immunization. Vaccine 21 (11-12) : 1195-1204. ScholarBank@NUS Repository. https://doi.org/10.1016/S0264-410X(02)00485-1 | |
dc.identifier.issn | 0264410X | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/47896 | |
dc.description.abstract | The mite protein Der p 1 is a major trigger of allergy and atopic asthma world-wide, and thus, a good vaccine candidate for allergy prevention. Since it is a cysteine protease, the catalytic effects of Der p 1 vaccination may be unpredictable. One approach to reduce this risk is to vaccinate with DNA encoding enzymatically inactive forms of Der p 1. Here we show that Der p 1 DNA without its native pre-pro sequences potently induced Der p 1-specific antibodies, as long as its pre-sequence was substituted by another leader sequence. Without any pre-pro sequence, the same DNA fragment was well expressed but failed to induce significant level of anti-Der p 1 antibodies, without further boosting by protein. © 2002 Elsevier Science Ltd. All rights reserved. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0264-410X(02)00485-1 | |
dc.source | Scopus | |
dc.subject | Der p 1 | |
dc.subject | DNA vaccine | |
dc.subject | Naked DNA | |
dc.type | Article | |
dc.contributor.department | PAEDIATRICS | |
dc.description.doi | 10.1016/S0264-410X(02)00485-1 | |
dc.description.sourcetitle | Vaccine | |
dc.description.volume | 21 | |
dc.description.issue | 11-12 | |
dc.description.page | 1195-1204 | |
dc.description.coden | VACCD | |
dc.identifier.isiut | 000181058800023 | |
Appears in Collections: | Staff Publications |
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