Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/47638
Title: IDENTIFICATION OF CANDIDATE GLYCOSAMINOGLYCANS INVOLVED IN MURINE PRIMARY SPINAL NEURULATION
Authors: LEONG SHU XIAN GRACE
Keywords: Glycosaminoglycans, Proteoglycans, Neurulation, Sulfatases, Glypicans, NTDs
Issue Date: 17-Aug-2012
Source: LEONG SHU XIAN GRACE (2012-08-17). IDENTIFICATION OF CANDIDATE GLYCOSAMINOGLYCANS INVOLVED IN MURINE PRIMARY SPINAL NEURULATION. ScholarBank@NUS Repository.
Abstract: Glycosaminoglycans are associated with ligand presentation in regulating various biological processes, including cellular growth, migration and adhesion. In spinal neurulation, they may be involved in posterior neuropore closure, which proceeds through three progressive modes marked by formation of different hinge points through morphogenetic changes of neuroepithelial cells. Sulfatase-1 is a glycosaminoglycan-modifying enzyme; Glypican-1 is a proteoglycan that contains glycosaminoglycan chains. Through transcriptome profiling and immunohistochemistry, the expression of these two molecules was found to increase during posterior neuropore closure. Further, silencing either of these molecules led to decreased migration and increased proliferation and adhesion of neuroepithelial cells. Together, the data suggest that both Sulfatase-1 and Glypican-1 may regulate closure of the posterior neuropore during primary spinal neurulation.
URI: http://scholarbank.nus.edu.sg/handle/10635/47638
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