Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/47632
Title: POLYELECTROLYTE MATERIALS BASED CARRIER SYSTEMS FOR CONTROLLED RELEASE OF PROTEIN AND INTRACELLULAR DRUG DELIVERY
Authors: SHE ZHEN
Keywords: polyelectrolyte, controlled release, microcapsule, release mechanism, basic fibroblast growth factor, 5-fluorouracil
Issue Date: 18-Jun-2012
Source: SHE ZHEN (2012-06-18). POLYELECTROLYTE MATERIALS BASED CARRIER SYSTEMS FOR CONTROLLED RELEASE OF PROTEIN AND INTRACELLULAR DRUG DELIVERY. ScholarBank@NUS Repository.
Abstract: Polyelectrolyte materials based carrier system for controlled release (CR) of bioactive proteins and delivery of anti-cancer drugs are of interest to our research due to their good biocompatibility and biodegradability. In the first part of this study, polyelectrolyte multilayer microcapsules prepared via Layer-by-Layer (LbL) method were used for CR of fluorescent bovine serum albumin (BSA). By investigating the impact of different loading approaches, shell compositions, and shell thicknesses and release environments on BSA release, the shell permeability related protein release mechanism was revealed. In the second part, microcapsules prepared by the same method were applied in CR of basic fibroblast growth factor (FGF2) and their advantages in maintaining the bioactivity of FGF2 and enhancing cell proliferation were evaluated in vitro. As the micro-size carrier has drawbacks in intracellular drug delivery, in the third part, a polyelectrolyte-TiO2 nanocomposite carrier system was developed for anti-cancer drug delivery and through this a surface chemistry related synergistic anti-cancer effect was discovered.
URI: http://scholarbank.nus.edu.sg/handle/10635/47632
Appears in Collections:Ph.D Theses (Open)

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