Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/47626
Title: CHARACTERIZATION OF BIOFILM FORMATION BY HELICOBACTER PYLORI
Authors: HASSANBHAI AMMAR MANSOOR
Keywords: Helicobacter pylori, biofilms, survival, proteomannan, Enterovirus 71, micropillars
Issue Date: 14-Nov-2012
Source: HASSANBHAI AMMAR MANSOOR (2012-11-14). CHARACTERIZATION OF BIOFILM FORMATION BY HELICOBACTER PYLORI. ScholarBank@NUS Repository.
Abstract: H. pylori is an important gastric pathogen that forms biofilm under poor nutrient conditions, defined pH and temperature. Furthermore, biofilm formation is strain dependent. Importantly, H. pylori remains viable for nine weeks in the in vitro biofilm, signifying its ability in surviving extragastrically over long periods. When analyzed by gas chromatography-mass spectrometry, the biofilm revealed the presence of mannose as the main sugar component in the biofilm. Study using its adhesin isogenic mutants indicates the importance of colonization as an essential factor in the development of biofilm. In addition, co-culturing with other enteric-organisms like Enterovirus (EV71) shows that the biofilm protects the virus in vitro. Interestingly, mechanical insights demonstrate that both planktonic and sessile biofilm H. pylori exerts ¿mechanical¿ forces on host cells during infection. Taken together, the data demonstrates H. pylori biofilms promoting survivability as well as contributing an important role in transmission and infections.
URI: http://scholarbank.nus.edu.sg/handle/10635/47626
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