Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/47625
Title: EVALUATION OF ANTI-PROLIFERATIVE ACTIVITY AND HEPATOTOXICITY OF BOTANICALS AND BOTANICAL HEALTH PRODUCTS
Authors: PATEL DHAVALKUMAR NARENDRABHAI
Keywords: Panax notoginseng, anti-proliferative activity, drug discovery, botanical health products,adverse events, hepatotoxicity
Issue Date: 4-Dec-2012
Source: PATEL DHAVALKUMAR NARENDRABHAI (2012-12-04). EVALUATION OF ANTI-PROLIFERATIVE ACTIVITY AND HEPATOTOXICITY OF BOTANICALS AND BOTANICAL HEALTH PRODUCTS. ScholarBank@NUS Repository.
Abstract: Botanical medicine has been used since time immemorial for their beneficial effects but some botanicals may also cause adverse events. Hence, it is important to evaluate holistically both the efficacy and safety of botanical medicine. The objectives of this work are (1) to evaluate the potential anti-proliferative activity of steamed Panax notoginseng, (2) to investigate the potential hepatotoxicity of 15 botanical health products suspected to cause drug induced liver injury and (3) to analyse adverse events reports associated with the use of complementary medicine and health supplements in Singapore. Seven major marker compounds (ginsenosides) of steamed P. notoginseng were isolated and screened for their potential anti-proliferative activity against selected liver cancer cell lines. The pharmacokinetics and mechanism of action of selected ginsenosides were also studied. Potential hepatotoxic compounds from selected botanical health products were identified, quantified and their effects on human hepatocytes (THLE-2 cells) were evaluated. Potential mechanisms of toxicity were also investigated.
URI: http://scholarbank.nus.edu.sg/handle/10635/47625
Appears in Collections:Ph.D Theses (Open)

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