Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/47619
Title: RECRUITMENT OF P63-EXPRESSING DEEP AIRWAY STEM CELLS FOR LUNG REPAIR FOLLOWING H1N1 INFLUENZA INFECTION IN MICE
Authors: POOJA ASHOK KUMAR
Keywords: Influenza, mouse, airway, stem cells, alveoli, p63 Krt5
Issue Date: 13-Jul-2012
Source: POOJA ASHOK KUMAR (2012-07-13). RECRUITMENT OF P63-EXPRESSING DEEP AIRWAY STEM CELLS FOR LUNG REPAIR FOLLOWING H1N1 INFLUENZA INFECTION IN MICE. ScholarBank@NUS Repository.
Abstract: The potential role of adult stem cells in lung repair following catastrophic damage remains obscure. Here we employ a murine-adapted H1N1 influenza virus related to that of the 1918 pandemic to introduce widespread but survivable damage to all regions of the mouse airways. We find that p63-expressing stem cells in the bronchiolar epithelium undergo massive proliferation after infection followed by a concerted radiation to interbronchiolar regions of alveolar ablation. Once there, these cells proliferate into discrete, Krt5+ pods and initiate the expression of markers typical of type I pneumocytes. Gene expression profiles of lung containing these pods suggest that they participate in a process of reconstituting the alveolar-capillary network eradicated by viral infection. This dynamics of this p63-expressing stem cell in lung repair mirror recent findings that pedigrees of human deep airway stem cells assemble alveoli-like structures in vitro and suggest new therapeutic avenues to acute and chronic airway disease.
URI: http://scholarbank.nus.edu.sg/handle/10635/47619
Appears in Collections:Ph.D Theses (Open)

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