Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/47552
Title: EPAS1 REGULATION AND FUNCTION IN THE HUMAN TROPHOBLAST
Authors: NORHAM ERLYANI BTE ABDUL HAMID
Keywords: trophoblast,placenta,hypoxia,EPAS1,HIF,RNA-Seq
Issue Date: 5-Apr-2013
Source: NORHAM ERLYANI BTE ABDUL HAMID (2013-04-05). EPAS1 REGULATION AND FUNCTION IN THE HUMAN TROPHOBLAST. ScholarBank@NUS Repository.
Abstract: Early development in humans occur in an environment of low oxygen. Placental perfusion only begins upon the removal of these plugs, between 10 to 12 weeks of gestation. The sudden presence of blood at the end of the first trimester brings with it oxygenation, drastically modifying the uterine environment. EPAS1, a transcription factor responding in low oxygen, has been implicated in placental development and function. To study its role, this thesis took a two-pronged approach. Firstly, I studied an EPAS1 SNP found in native Tibetan highlanders, which recently emerged with the strongest signal of natural selection. Secondly, I identified EPAS1 targets via ChIP-Seq, and verified these targets by comparing their expression between the 7- to 9-week old and 13- to 15-week old human placenta. Additionally, the global in vivo data enabled us to identify biological processes activated upon placental perfusion.
URI: http://scholarbank.nus.edu.sg/handle/10635/47552
Appears in Collections:Ph.D Theses (Open)

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