Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/47540
Title: NATURAL IgG IS INNATE IMMUNE RESPONSIVE¿ ELUCIDATION OF MECHANISMS OF ACTION
Authors: SASWATI PANDA
Keywords: Innate immunity, Natural IgG, local acidosis, hypocalcemia, lectins, C3-independent
Issue Date: 24-Jan-2013
Source: SASWATI PANDA (2013-01-24). NATURAL IgG IS INNATE IMMUNE RESPONSIVE¿ ELUCIDATION OF MECHANISMS OF ACTION. ScholarBank@NUS Repository.
Abstract: Natural antibodies, which pre-exist in neonates and uninfected individuals, have remained a biological enigma due to lack of affinity for pathogens, when studied in isolation. This thesis work shows that infection-mediated local acidosis and hypocalcaemia increases the affinity of natural IgG for pathogen-associated lectin PRRs such as ficolin. Tethered on the bacterial surface, the IgG:ficolin complex is bridged to Fc gamma receptor on the phagocyte, thus linking humoral to cellular immunity. We defined the precise binding sites between the proteins. We found that natural IgG displays broad antibacterial activity, independent of complement. Knockout mice lacking IgG showed increased mortality during infection while reconstitution with natural IgG conferred protection. Our findings reveal a fundamentally vital mechanistic role of natural IgG in innate immunity.
URI: http://scholarbank.nus.edu.sg/handle/10635/47540
Appears in Collections:Ph.D Theses (Open)

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