Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/47538
Title: DEVELOPING PLATINUM NANOPARTICLES FOR ACTIVE TARGETING OF LIVER CANCER IN ZEBRAFISH
Authors: TEOW YIWEI
Keywords: platinum, nanoparticles, targeting, toxicity, cancer, zebrafish
Issue Date: 6-Sep-2012
Source: TEOW YIWEI (2012-09-06). DEVELOPING PLATINUM NANOPARTICLES FOR ACTIVE TARGETING OF LIVER CANCER IN ZEBRAFISH. ScholarBank@NUS Repository.
Abstract: Engineered nanomaterials are synthesized and explored for potential use in consumer and medical products. In this work, we explore the use of nanoparticles in the field of drug delivery, especially in cancer. Cancer is a disease which involves unregulated cell growth. Chemotherapeutic drugs kill cancer cells which are dividing rapidly but in the process, also harm normal cells and could result in serious side effects. Targeted drug delivery vehicles can help overcome toxicity by delivering the drug to the target of interest. Conventional drugs are governed by absorption, distribution, metabolism and excretion and these dictates concentrations, kinetics and performance of a drug. Nanoparticles emerge as a useful delivery vehicle for poorly soluble drugs and at the same time, also exhibit targeting properties. Platinum nanoparticles with biological molecules as capping agents were synthesized, characterized and studied in vitro and in zebrafish larvae.
URI: http://scholarbank.nus.edu.sg/handle/10635/47538
Appears in Collections:Ph.D Theses (Open)

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