Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/47530
Title: EXPRESSION ANALYSIS AND FUNCTIONAL STUDY OF HS3ST3B1 IN HUMAN PROSTATE CANCER
Authors: KWAN LI JUAN
Keywords: Glycosaminoglycans, HS3ST3B1, prostate cancer, anti-tumour, biomarker
Issue Date: 4-Jun-2013
Source: KWAN LI JUAN (2013-06-04). EXPRESSION ANALYSIS AND FUNCTIONAL STUDY OF HS3ST3B1 IN HUMAN PROSTATE CANCER. ScholarBank@NUS Repository.
Abstract: Glycosaminoglycans have been found to participate in various cellular signaling events and are important regulators of tumour metastasis. Microarray analysis from a previous study (Teng, 2010) has indicated a downregulation of HS3ST3B1 in both prostate cancer cell lines and tissues. This was verified and downregulating HS3ST3B1 in normal prostate epithelial cell line RWPE-1 has promoted cellular migration, invasion and proliferation as well as inhibited cellular adhesion via an upregulation of OPN3. These results point to the potential role of HS3ST3B1 as a novel therapeutic target. It was also found that high HS3ST3B1 expression is associated with a lower risk of extraprostatic extension and perineural invasion as well as cancer involving unilateral lobe and lower pT2 stage, hence predicting a better prognosis. On the whole, my findings established the anti-tumour role of HS3ST3B1 in prostate cancer cellular behaviour and suggested it to be a good biomarker of prostate cancer progression.
URI: http://scholarbank.nus.edu.sg/handle/10635/47530
Appears in Collections:Master's Theses (Open)

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