Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/47521
Title: DESIGN OF BLOCK COPOLYMERS AND THEIR SUPRAMOLECULAR SELF-ASSEMBLY FOR DRUG DELIVERY
Authors: ZHU JINGLING
Keywords: block copolymer, self-assembly, drug delivery, cyclodextrin, hydrogel, nanovesicle
Issue Date: 22-Aug-2012
Source: ZHU JINGLING (2012-08-22). DESIGN OF BLOCK COPOLYMERS AND THEIR SUPRAMOLECULAR SELF-ASSEMBLY FOR DRUG DELIVERY. ScholarBank@NUS Repository.
Abstract: In this thesis, polyhydroxybutyrate (PHB)-based block copolymers of different functional groups and macromolecular architectures were synthesized through the combination of ring opening polymerization (ROP) and click chemistry. The self-assembly behavior of PHB-based amphiphilic block copolymers in aqueous solution was studied. Furthermore, two host-guest pairs, a-Cyclodextrin/ Polyethylene glycol and ß-Cyclodextrin/Adamantane were employed as driving forces in constructing supramolecular self-assemblies from PHB-based block copolymers and cyclodextrins (CDs). The supramolecular hydrogels and nanostructures were demonstrated to have great potential to be used as drug delivery systems.
URI: http://scholarbank.nus.edu.sg/handle/10635/47521
Appears in Collections:Ph.D Theses (Open)

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