Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/47403
Title: THE UNIQUE PHYLOGENETIC DISTRIBUTION OF VAULT PARTICLES REVEALS ITS FUNCTIONAL ROLES
Authors: ASFA ALLI SHAIK
Keywords: Vault complex, MVP, Evolution, Heterotrophs, Nutrient storage, Trypanosoma brucei
Issue Date: 28-Mar-2013
Source: ASFA ALLI SHAIK (2013-03-28). THE UNIQUE PHYLOGENETIC DISTRIBUTION OF VAULT PARTICLES REVEALS ITS FUNCTIONAL ROLES. ScholarBank@NUS Repository.
Abstract: Since its discovery in 1986, the function of the 13 million Dalton vault complex has remained perplexing. Approximately three times larger than the ribosome, it is the largest ribonucleoprotein complex within the eukaryotic cell. Though implicated in a wide variety of cellular roles, lack of a distinct phenotype in knockout models has kept the precise function of these particles ambiguous. The current work focuses on unraveling the unique evolutionary history of vaults to track its origin, and also identify any subtle unifying traits in organisms with vault genes. The observations are consistent with an ancestral function for vaults as a stable amino acid storage complex complementing loss of nitrogen fixation and amino acid biosynthesis. The efficacy of vault as an amino acid storage polymer was tested using compositional and theoretical biochemical analysis. The nutrient-related roles of vaults were also evaluated in an ancient single-celled eukaryote, Kinetoplastid Trypanosoma brucei.
URI: http://scholarbank.nus.edu.sg/handle/10635/47403
Appears in Collections:Ph.D Theses (Open)

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