Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/47346
Title: In vitro and in vivo studies into the antidiabetic and antilipidemic effects of chlorogenic acid
Authors: ONG KHANG WEI
Keywords: Vernonia amygdalina, chlorogenic acid, diabetes, gluconeogenesis, glucose transport, GLUT 4
Issue Date: 8-Jan-2013
Source: ONG KHANG WEI (2013-01-08). In vitro and in vivo studies into the antidiabetic and antilipidemic effects of chlorogenic acid. ScholarBank@NUS Repository.
Abstract: The present author investigated the effects of CGA on glucose and lipid metabolism in Leprdb/db mice. Hepatoma HepG2 was used to investigate CGA?s effect on hepatic glucose production and fatty acid synthesis while L6 myotubes was used to further strengthen our findings in animal skeletal muscles. Subsequently, he attempted to evaluate whether these effects of CGA are associated with the activation of AMPK. In Leprdb/db mice, acute treatment with CGA lowered AUCglucose in an OGTT. Chronic administration of CGA inhibited hepatic G6Pase expression and activity, attenuated hepatic steatosis, improved lipid profiles and skeletal muscle glucose uptake, which in turn improved fasting glucose level, glucose tolerance, insulin sensitivity and dyslipidemia in Leprdb/db mice. CGA activated CAMKK and AMPK, leading to subsequent beneficial metabolic outcomes, such as suppression of hepatic glucose production, fatty acid synthesis and glucose uptake in skeletal muscles. In conclusion, CGA improved glucose and lipid metabolism, via the CAMKK-dependent activation of AMPK.
URI: http://scholarbank.nus.edu.sg/handle/10635/47346
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Ong KWs Thesis (Final).pdf4.89 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

202
checked on Dec 11, 2017

Download(s)

1,196
checked on Dec 11, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.