Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jds.2012.02.002
Title: Interrelationships of periodontitis and diabetes: A review of the current literature
Authors: Chang, P.-C. 
Lim, L.P. 
Keywords: Advanced glycation end products
Diabetes
Periodontitis
Proinflammatory cytokines
Issue Date: 2012
Source: Chang, P.-C., Lim, L.P. (2012). Interrelationships of periodontitis and diabetes: A review of the current literature. Journal of Dental Sciences 7 (3) : 272-282. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jds.2012.02.002
Abstract: Diabetes and periodontitis are common chronic diseases in the world, and abundant epidemiological evidence implies a bidirectional relationship between the two diseases. It appears that diabetes is a risk factor for greater periodontal destruction, whereas managing periodontitis can also contribute to better glycemic control. The underlying regulatory mechanisms are also bidirectional. The hyperglycemic status may directly alter subgingival microbial compositions, impair cellular function, and change collagen metabolism. The formation of advanced glycation end-products (AGEs) can further modify the extracellular matrix, and establishment of cellular receptor binding can amplify inflammation. Moreover, periodontitis also induces hyperlipidemia and insulin resistance. This cyclical relationship converges via overproduction of proinflammatory cytokines, such as tumor necrosis factor-α and interleukin-1β. Thus, this article highlights the importance of maintaining periodontal health to eliminate systemic complications and meticulous metabolic control to prevent further periodontal destruction. From a systemic aspect, targeting proinflammatory cytokines or receptors of AGEs could be a potential modality for treating periodontitis. Copyright © 2012, Association for Dental Sciences of the Republic of China. Published by Elsevier Taiwan LLC. All rights reserved.
Source Title: Journal of Dental Sciences
URI: http://scholarbank.nus.edu.sg/handle/10635/47175
ISSN: 19917902
DOI: 10.1016/j.jds.2012.02.002
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