Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.biosystems.2012.06.001
DC Field | Value | |
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dc.title | A cell state splitter and differentiation wave working-model for embryonic stem cell development and somatic cell epigenetic reprogramming | |
dc.contributor.author | Lu, K. | |
dc.contributor.author | Cao, T. | |
dc.contributor.author | Gordon, R. | |
dc.date.accessioned | 2013-10-16T07:24:30Z | |
dc.date.available | 2013-10-16T07:24:30Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Lu, K., Cao, T., Gordon, R. (2012). A cell state splitter and differentiation wave working-model for embryonic stem cell development and somatic cell epigenetic reprogramming. BioSystems 109 (3) : 390-396. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biosystems.2012.06.001 | |
dc.identifier.issn | 03032647 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/47163 | |
dc.description.abstract | Cell fate determination and development is a biology question that has yet to be fully answered. During embryogenesis and . in vivo stem cell differentiation, cells/tissues deploy epigenetic mechanisms to accomplish differentiation and give rise to the fully developed organism. Although a biochemistry description of cellular genetics and epigenetics is important, additional mechanisms are necessary to completely solve the problem of embryogenesis, especially differentiation and the spatiotemporal coordination of cells/tissues during morphogenesis. The cell state splitter and differentiation wave working-model was initially proposed to explain the homeostatic primary neural induction in amphibian embryos. Here the model is adopted to explain experimental findings on . in vitro embryonic stem cell, pluripotency and differentiation. Moreover, since somatic cells can be reverted to a stem-cell-like pluripotent state through the laboratory procedure called epigenetic reprogramming, erection of a cell state splitter could be a key event in their successful reprogramming. Overall, the cell state splitter working-model introduces a bistable cytoskeletal mechanism that partially explains cell fate determination and biological development. It offers an interdisciplinary framework that bridges the gap between molecular epigenetics and embryogenesis. © 2012 Elsevier Ireland Ltd. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.biosystems.2012.06.001 | |
dc.source | Scopus | |
dc.subject | Dedifferentiation | |
dc.subject | Development | |
dc.subject | Differentiation | |
dc.subject | Embryogenesis | |
dc.subject | Embryonic stem cell | |
dc.subject | Epigenetics | |
dc.subject | Induced pluripotent stem cell | |
dc.subject | Mechanobiology | |
dc.subject | Mechanotransduction | |
dc.subject | Organizer | |
dc.subject | Reprogramming | |
dc.subject | Theoretical biology | |
dc.subject | Transdifferentiation | |
dc.type | Article | |
dc.contributor.department | DENTISTRY | |
dc.description.doi | 10.1016/j.biosystems.2012.06.001 | |
dc.description.sourcetitle | BioSystems | |
dc.description.volume | 109 | |
dc.description.issue | 3 | |
dc.description.page | 390-396 | |
dc.description.coden | BSYMB | |
dc.identifier.isiut | 000308840500013 | |
Appears in Collections: | Staff Publications |
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