Please use this identifier to cite or link to this item:
|Title:||Directing stem cell differentiation into the chondrogenic lineage in vitro|
|Authors:||Boon, C.H. |
|Citation:||Boon, C.H., Cao, T., Eng, H.L. (2004). Directing stem cell differentiation into the chondrogenic lineage in vitro. Stem Cells 22 (7) : 1152-1167. ScholarBank@NUS Repository. https://doi.org/10.1634/stemcells.2004-0062|
|Abstract:||A major area in regenerative medicine is the application of stem cells in cartilage tissue engineering and reconstructive surgery. This requires well-defined and efficient protocols for directing the differentiation of stem cells into the chondrogenic lineage, followed by their selective purification and proliferation in vitro. The development of such protocols would reduce the likelihood of spontaneous differentiation of stem cells into divergent lineages upon transplantation, as well as reduce the risk of teratoma formation in the case of embryonic stem cells. Additionally, such protocols could provide useful in vitro models for studying chondrogenesis and cartilaginous tissue biology. The development of pharmacokinetic and cytotoxicity/ genotoxicity screening tests for cartilage-related biomaterials and drugs could also utilize protocols developed for the chondrogenic differentiation of stem cells. Hence, this review critically examines the various strategies that could be used to direct the differentiation of stem cells into the chondrogenic lineage in vitro.|
|Source Title:||Stem Cells|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Oct 17, 2018
WEB OF SCIENCETM
checked on Oct 9, 2018
checked on Jul 13, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.