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Title: Mineralized bone loss in partially edentulous trabeculae of ovariectomized rabbit mandibles
Authors: Cao, T. 
Shirota, T.
Ohno, K.
Michi, K.I.
Keywords: Histomorphometry
Mandibular trabeculae
Issue Date: 2004
Citation: Cao, T., Shirota, T., Ohno, K., Michi, K.I. (2004). Mineralized bone loss in partially edentulous trabeculae of ovariectomized rabbit mandibles. Journal of Periodontal Research 39 (1) : 37-41. ScholarBank@NUS Repository.
Abstract: Objective: The purpose of this study was to evaluate trabeculae changes in partially edentulous bone in ovariectomized rabbits. Background: Numerous clinical studies have suggested that the greater risk for oral bone loss in females may be correlated with osteoporosis after menopause. Knowledge of trabecular changes in partially edentulous bone in animals with loss of ovarian function may be beneficial in the diagnosis and treatment of partially edentulous patients of postmenopausal women. Methods: Twelve adult female Japanese white rabbits were examined. The mandibular incisors were initially extracted to simulate the partially edentulous bone. Six animals were bilaterally ovariectomized and the other six sham-ovariectomized 12 weeks after tooth extraction. The partially edentulous parts of distal mandibular bodies were processed undecalcified 12 weeks after ovariectomized or sham-ovariectomized surgeries and examined by quantitative trabecular bone histomorphometry. Results: In ovariectomized rabbits, there were significant increases in trabecular separation, osteoid volume, osteoid thickness, osteoid width, eroded surface, and mineral apposition rate, and a significant decrease in trabecular number. Conclusion: The results of sparser trabecular structure, more trabecular osteoid, and increased trabecular bone turnover demonstrate mineralized bone loss in partially edentulous trabeculae of ovariectomized rabbit mandibles and suggest that the same loss may occur in postmenopausal women.
Source Title: Journal of Periodontal Research
ISSN: 00223484
DOI: 10.1111/j.1600-0765.2004.00703.x
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