Please use this identifier to cite or link to this item: https://doi.org/10.1117/12.822851
Title: Influence of bacterial interactions on the susceptibility to photodynamic inactivation
Authors: Upadya, M.H.
Tegos, G.
Hamblin, M.
Kishen, A. 
Keywords: biofilm
efflux pump inhibitor
Enterococcus faecalis
photodynamic therapy
Issue Date: 2009
Source: Upadya, M.H., Tegos, G., Hamblin, M., Kishen, A. (2009). Influence of bacterial interactions on the susceptibility to photodynamic inactivation. Progress in Biomedical Optics and Imaging - Proceedings of SPIE 7380 : -. ScholarBank@NUS Repository. https://doi.org/10.1117/12.822851
Abstract: Photodynamic therapy has emerged as a possible supplement to the existing protocols for endodontic disinfection. Microbes are known to gain significant ecological advantage when they survive as coaggregates and biofilms in an infected tissue. Such microbial coaggregates and biofilms have been confirmed to play a key role in the pathogenicity of many infections. So far, not many studies have correlated the efficacy of antimicrobial photodynamic inactivation (APDI) to the different modes of bacterial growth. This study aims to evaluate the APDI of 3 strains of Enterococcus faecalis in planktonic phase, in a co-aggregated suspension and in a 4-day old biofilm. The results showed that the biofilm mode of growth offered the greatest resistance to APDI and the inclusion of an efflux pump inhibitor significantly increased the APDI of biofilm bacteria. From this study, we conclude that APDI of bacteria in biofilms is the most challenging and that the use of bacterial efflux pump inhibitors enhances its photodynamic antibiofilm efficacy. © 2009 Copyright SPIE - The International Society for Optical Engineering.
Source Title: Progress in Biomedical Optics and Imaging - Proceedings of SPIE
URI: http://scholarbank.nus.edu.sg/handle/10635/47015
ISBN: 9780819476609
ISSN: 16057422
DOI: 10.1117/12.822851
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