Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/43564
Title: CONJUGATED POLYMERS FOR TWO-PHOTON BIOMEDICAL APPLICATIONS
Authors: SHEN XIAOQIN
Keywords: Conjugated Polymer, Two-Photon, Photodynamic Therapy, Imaging
Issue Date: 14-Jan-2013
Source: SHEN XIAOQIN (2013-01-14). CONJUGATED POLYMERS FOR TWO-PHOTON BIOMEDICAL APPLICATIONS. ScholarBank@NUS Repository.
Abstract: Two-photon photodynamic therapy (TP-PDT) is a promising noninvasive cancer treatment with high spatial resolution and deep tissue penetration. However, the lack of efficient two-photon photosensitizers limits the practical application of TP-PDT. Conjugated polymers are known to be a class of promising materials with excellent light harvesting properties. The purpose of this thesis is to synthesize and develop conjugated polymers for TP-PDT and two-photon imaging applications. First, water soluble polyfluorene-based conjugated polymers are synthesized and studied for amplification of two-photon properties of photosensitzers through fluorescence resonance energy transfer (FRET). Second, photosensitizer doped conjugated polymer nanoparticles are developed and studied for enhancement of two-photon induced singlet oxygen generation. Then biocompatible nanoparticles are prepared and demonstrated for TP-PDT with two-photon imaging capability. Third, novel water soluble conjugated polymers with large two-photon absorption cross sections are synthesized and developed as novel two-photon photosensitzers for TP-PDT and TP imaging applications. At last, high efficient conjugated polymer based nanophotosenstizers are developed for targeted TP-PDT.
URI: http://scholarbank.nus.edu.sg/handle/10635/43564
Appears in Collections:Ph.D Theses (Open)

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