Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/43524
Title: DIVERSITY OF HUMAN LEUKOCYTE ANTIGENS (HLA) AND KILLER IMMUNOGLOBULIN-LIKE RECEPTORS (KIR) IN THE SINGAPORE MALAY
Authors: SHEN MEIXIN
Keywords: HLA, KIR, allele frequency, B*15:02, extended haplotype homozygosity, linkage disequilibrium
Issue Date: 25-Jan-2013
Source: SHEN MEIXIN (2013-01-25). DIVERSITY OF HUMAN LEUKOCYTE ANTIGENS (HLA) AND KILLER IMMUNOGLOBULIN-LIKE RECEPTORS (KIR) IN THE SINGAPORE MALAY. ScholarBank@NUS Repository.
Abstract: Epistatic interactions between MHC class I loci and KIR influence the outcome of immune surveillance and reproductive fitness. Recent evidence suggests that the two gene clusters are co-evolving, resulting in distinct allelic and haplotypic frequencies observed in different populations. A third of the Singapore Malay carried the canonical KIR A/A genotype and high frequencies of C*04:01 carriers were noted within this subpopulation. Because C*04:01 is a ligand for KIR2DL1 and KIR2DS4 from the KIR A haplotype, it hinted to possible co-evolution of the two gene clusters. In addition, the SNP haplotype structure of the MHC revealed the homology of three closely related B*15 alleles (B*15:02, B*15:13, and B*15:21) near the HLA-B locus and two distinct lineages of the C*08:01-B*15:02 haplotype in the Malay. Furthermore, the congruence of the C*08:01-B*15:02 haplotype between Malay and Chinese with only minimal block shuffling hinted to the common origin of B*15 haplotypes in both ethnicities. These findings can be applied to other conserved HLA haplotypes to reveal the relative age and ancestries of closely related alleles. In conclusion, this study demonstrates the unique HLA and KIR allelic and haplotypic frequencies in the Malay that will contribute to our understanding of the population¿s adaption to regional environmental conditions.
URI: http://scholarbank.nus.edu.sg/handle/10635/43524
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