Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/43464
Title: FUNCTIONAL SIGNIFICANCE OF SEQUENCE VARIATIONS IN HEPATITIS B VIRUS X PROTEIN
Authors: OH MAN HUAN VERONICA
Keywords: sequence, variations, Hepatitis B, HBx, Functions
Issue Date: 28-Mar-2013
Source: OH MAN HUAN VERONICA (2013-03-28). FUNCTIONAL SIGNIFICANCE OF SEQUENCE VARIATIONS IN HEPATITIS B VIRUS X PROTEIN. ScholarBank@NUS Repository.
Abstract: Hepatitis B virus (HBV) infection is a major health problem globally and is classified into eight major genotypes, which exhibit virological and clinical differences. Hepatitis B virus X protein (HBx, 154 amino-acids), is a key regulatory protein modulating viral replication and pathogenesis. However, the functional roles of HBx encoded by the eight different HBV genotypes are yet to be defined. In this study, HBx genotype B was found to modulate cellular functions that could potentially reduce viral persistence. We have also demonstrated that NF-kB activation can be affected by genotype-specific amino acid residues Arg78, Arg87, Asn88 and Glu119 of HBx protein. After HBV infection, integration of HBx gene into host genomes often result in carboxyl-terminal truncations of HBx protein. The carboxyl-terminal 20 amino acids of HBx, in particular Cys137 and His139, were shown to be crucial in modulating viral replication and NF-kB activation. Taken together, these findings demonstrate the impact of sequence variations on HBx functions.
URI: http://scholarbank.nus.edu.sg/handle/10635/43464
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